The nucleus reuniens, a thalamic relay for cortico-hippocampal interaction in recent and remote memory consolidation

The consolidation of declarative memories is believed to occur mostly during sleep and involves a dialogue between two brain regions, the hippocampus medial prefrontal cortex. information encoded experience by neuronal assemblies replayed leading progressive strengthening integration memory trace in gradual transfer from cortex for long-term storage requires synchronization cortico-hippocampal networks different oscillations, like ripples, spindles, slow oscillations. Recent studies suggest involvement third partner, nucleus reuniens, consolidation. Its bidirectional connections with place reuniens key position relay structures. Indeed, many topical works reveal original role that occupies recent remote This review aimed examine these contributions, as well its functional embedment this complex network, provide some insights on possible mechanisms.